Pulmonary arterial hemodynamic in patients with or without pulmonary disease admitted after cardiac arrest - a sub study of the BOX trial

Abstract Funding Acknowledgements Type of funding sources: Foundation. Main source(s): Novo Nordisk Foundation Background Patients with pulmonary disease may have altered hemodynamic compared to patients without disease. We hypothesize that these pre-existing significantly elevated arterial pressure during the first 48 hours ICU-stay. Methods The BOX-trial was an investigator-initiated, randomized, controlled study targeted MAP (63 vs 77 mmHg) and PaO2 (9-10 13-14 kPa) interventions in 789 comatose OHCA (of presumed cardiac origin) patients. Pre-existing, significant recorded at baseline. underwent serial assessments artery catheter time insertion (0 h), 6 h, 12 24 36 h h. Among parameters output (CO). Pulmonary pressures central venous were measured continuously. Patient characteristics included age, return spontaneous circulation (ROSC) initial rhythm. Results Hemodynamic from 730 analysed, which 89 (12%) had Of these, 57 (8%) COPD, 26 (4%) asthma (1%) non-obstructive older (66±12 62±14 years) similar ROSC (20±14 23±16 minutes). Initial shockable rhythm present 73/89 (82%) 580/641 (90%) without, p=0.015. At hours, mean (27±5 24±6 p<0.0001, see Figure 1), systolic (36±7 33±8 p=0.0004), diastolic (21±5 18±5 p<0.0001) all higher for than without. This association remain statistically significant, when adjusting primary rhythm, age. Also, heart rate (72±21 66±17 bpm, p<0.0056) Cardiac index (cardiac adjusted body surface), mixed saturation CVP between groups. Conclusions Pre-existing resuscitated OHCA-patients is associated pressures.